With investors continuing to be unnerved by the prospect of Donald Trump winning next week's US presidential election, leading shares are on the slide again.
Pharmaceutical shares are under pressure after US lawmakers called on federal regulators to open a probe on potential price fixing for insulin and diabetes drugs.
Although not mentioned, Hikma is the biggest faller in the FTSE 100, down 146p at 15.99 pounds after HSBC analysts cut their target price from 25.25 pounds to 19.85 pounds and warned all generic drugmakers could become caught up in a US Department of Justice investigation.
But Numis moved from hold to buy ahead of an update from Hikma next week:
Overall the FTSE 100 has fallen 95.11 points to 6695.40, on track for its biggest one day fall since the immediate aftermath of the Brexit vote. Connor Campbell, financial analyst at Spreadex, said:
The falls are across the board. British Airways owner International Airlines Group is down 16.1p to 434.7p despite telling investors it was sticking to its earnings and margins growth targets for now to 2020 despite the difficult trading environment.
Dixons Carphone is down 12.6p at 328.9p on concerns about a coming squeeze on UK consumer spending, while Randgold Resources has fallen 220p to 68.90. pounds But Paddy Power Betfair has bucked the trend, up 285p to 88.65 pounds after it increased its full year profit forecast from 365m pounds-385m pounds to 390m pounds-405m pounds, citing the benefits of a weaker pound on its euro revenues. It reported earnings of 113m pounds in the three months to the end of September, up 53%.
Among the mid-caps DFS Furniture has fallen nearly 13% to 230.1p as US private equity firm Advent International sold a 12% stake in the business at 240p a share, cutting its investment in the retailer in half.